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Moderate

Testosterone (total, men)

Serum total testosterone, ideally drawn fasting in the morning and confirmed on a second sample if the first comes back low. It affects muscle mass, bone density, libido, mood and erythropoiesis, and low levels are linked to reduced quality of life and, observationally, higher cardiometabolic risk. The distance between diagnosing hypogonadism and “optimising” a normal result is where most of the longevity marketing operates.

Why it grades Moderate

Lincoff AM, Bhasin S, Flevaris P, et al. (TRAVERSE) “Cardiovascular Safety of Testosterone-Replacement Therapy.” N Engl J Med 2023;389:107–117 randomised 5,246 hypogonadal men with symptoms and cardiovascular risk to testosterone gel or placebo. Testosterone was non-inferior for major adverse cardiac events, resolving a long-standing safety question, though nonfatal arrhythmia including atrial fibrillation was more frequent on treatment. Endocrine Society guidelines recommend testing only in men with symptoms of hypogonadism plus a confirmed low level — not as a routine screen in asymptomatic men.

Lincoff AM, et al. N Engl J Med. 2023. PubMed: PMID 37326322 · Full cost breakdown & who should test →

FrequencyOn symptoms only — not a routine annual test
Cost (SGD)S$30.60–38.15 (total); S$125–147.15 for combined/free testosterone panels
Appropriate forSymptomatic men (low libido, fatigue, erectile dysfunction, loss of muscle mass) or conditions associated with hypogonadism

Singapore pricing. We have a full price breakdown for this test, using checked 2026 figures from named providers — read the price guide →