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Open Longevity Diagnostics, graded
Strong

Coronary Artery Calcium (CAC) Score

A non-contrast CT that quantifies calcified plaque in the coronary arteries and reports it as an Agatston score. The distinction that matters here: it does not estimate risk from risk factors, it images the disease itself. Calcified plaque is a direct, visible marker of atherosclerotic burden that is already present.

Why it grades Strong

Detrano R, Guerci AD, Carr JJ, et al. (MESA) “Coronary Calcium as a Predictor of Coronary Events in Four Racial or Ethnic Groups.” N Engl J Med 2008;358:1336–1345 followed 6,722 adults without known cardiovascular disease and found that a doubling of the calcium score raised the risk of a major coronary event by 15–35% across four racial and ethnic groups, independently of traditional risk factors. The 2018 ACC/AHA cholesterol guideline now incorporates CAC scoring as a formal decision aid: in intermediate-risk patients a score of zero can support deferring statin therapy, while a high score supports intensifying it. Arguably the best-evidenced “extra” test on this site.

Detrano R, et al. N Engl J Med. 2008. PubMed: PMID 18367736 · Full cost breakdown & who it's for →

FrequencyOnce around age 40–50 (intermediate risk); repeat testing is not usually indicated within 5 years if score is 0
Cost (SGD)S$300–550
Appropriate forAdults at intermediate calculated cardiovascular risk, to guide the statin decision. Not useful in very-low or very-high risk adults where the decision is already clear, and not recommended under ~age 40 without strong risk factors (low pre-test probability, some radiation exposure)

Singapore pricing. We have a full price breakdown for this test, using checked 2026 figures from named providers — read the price guide →